ENGG 4620/6620: Biomedical Imaging

ANNOUNCEMENTS

This course will be offered again in Fall 2020.

SUMMARY

Biomedical Imaging (3): Fundamental principles and applications of noninvasive imaging modalities in medicine (X-rays, tomography, magnetic resonance, ultrasound); computer methods and algorithms for image processing, enhancement and analysis.

Class schedule for Fall 2020:
TBD

CONTENTS

INTRODUCTION

Hardly any development in Medical Sciences has revolutionized medicine as much as the discovery that it was possible to look into the body without cutting. A hundred years ago, Conrad Wilhelm Röntgen discovered the X-rays. Since then, noninvasive imaging of the body literally got a new dimension with the invention of 3D tomography. CT and MRI allow to acquire cross-sectional images and to obtain three-dimensional reconstructions of structures. Two additional modalities will be covered, positron emission tomography (PET), which allows the imaging of tissue function. Particularly in conjunction with MRI, it allows new insights in the function of the brain. Ultrasound is a different modality. It is based on sound wave reflection, and its advantages are the relatively inexpensive equipment, and the radiation-free principle.

These fascinating techniques are the topic of this class. We will look at the physical principles of X-rays and magnetic resonance, as well as ultrasound imaging. The goal of this class is to understand physics and technology of those imaging modalities. The second half of the semester is dedicated to image processing and analysis. Most modern modalities rely heavily on computer processing of the measured data. Some image processing methods are inherent to the modality, such as the filtered backprojection in computed tomography or the Fourier transform of the k-space matrix in MRI. Of course, the computer can do more than provide the reconstructed images. Spatial measurements (e.g. the size of an embryo in ultrasound) and density (e.g. bone mineral density in osteoporosis) can easily be performed. The computer can also aid in enhancing image quality, suppression of noise and other artifacts, or in segmenting an object of interest - the separation of that object from surrounding image regions. The class will cover the four important steps of image enhancement, segmentation, quantification, and visualization.

SYLLABUS

The course syllabus is a general plan for the course; deviations may be necessary and will be announced to the class by the instructor.

Lecture block Topic
1 Introduction to Biomedical Imaging
History and development of Biomedical Imaging
2 Digital Images:
Properties and Processing
3 X-rays: Physics and instrumentation
X-ray tubes, X-ray attenuation in tissue
Film, image intensifiers, digital detectors
3 The Fourier transform
4 Computed Tomography: Principles
Reconstruction algorithms
Instruments and aplications
5 MRI: Physical foundations
Precession and spin echo
Gradient encoding
image reconstruction
6 Ultrasound Imaging
7 Beyond image formation:
Computerized Image processing
8 Statistical Image Description
Image Representation
9 Image Enhancement and Filtering
in the Spatial and Frequency Domain
10 Intensity-Based Segmentation
11 Morphological operators
12 Image Measurements and Quantification
13 Classification and
Decision Mechanisms
14 Outlook and Trends in Medical Imaging

BOOKS

Medical Imaging Technology by M.A. Haidekker, SpringerBriefs in Physics (2013)
Disclaimer: The author does not get royalty payments from the sale of this book

In addition, you need to obtain Chapters 2 and 3 of the book
Advanced Biomedical Image Analysis (M. Haidekker),
John Wiley & Sons, 2011
Follow this link to access the chapters on-line through our library


Recommended further reading:

Geoff Dougerty: "Digital Image Processing for Medical Applications",
Cambridge 2009, ISBN 978-0-521-86085-7
Excellent book that combines both the physics of imaging modalities and the computer processing steps needed for image formation and for further image processing. This book is a great complement for the class notes and strongly recommended.

Essential Physics of Medical Imaging
by G. Bushberg et al.
Lippincott Williams & Wilkins
This textbook covers all aspects of medical image acquisition. Presents an understanding of the theory and applications of the science including basic concepts, X-ray imaging, ultrasound, MRI, nuclear medicine, radiation protection, radiation dosimetry, and radiation biology. Abundant illustrations. This book is directed at students with a medical background.

The Image Processing Handbook
by John C. Russ
CRC Press
A very comprehensive and extensive book covering all aspects of image processing in Engineering and Science. Unfortunately, this comes at a relatively high price.

Digital Image Processing Algorithms and Applications
by Ioannis Pitas
Wiley-Interscience
This book is a good reference for those of you who are interested in actually programming those algorithms. It provides lots of C source code. However, algorithms are limited to entry-level image processing methods.

Magnetic Resonance Imaging: Physical Principles and Sequence Design
by E. Mark Haacke, Robert W. Brown, Michael R. Thompson, Ramesh Venkatesan
John Wiley & Sons
For those of you who really want to get into MRI, this book provides even more in-depth MRI knowledge, covering the special area of sequence design for specific medical and research applications

COMPUTER LAB AND SOFTWARE

Some homeworks will require the use of image processing software. If you have specific preferences, you may choose your own favorite software. In general, I recommend ImageJ. It is a widely used cross-platform software, and it is Free software so you can install and run it on your own computers.

For in-class demos, I usually use my own Crystal Image, because it has several features that I need for live demonstrations. This software is also Free (download from the above link), but it requires Linux.

The following needs to go the the first IJ homework:

ImageJ on the Mac: Permission to run third-party software needs to explicitly granted. The following point-by-point instructions are courtesy of Juhi Mancha (thanks!!):

GRADING

The grade will be based roughly in equal parts on the homeworks, the midterm exam, and the final exam. You will receive score points based on the fill-the-bucket principle, i.e. for each homework assignment and for each test, you accrue score points. Your final grade will be determined from the score you achieved relative to the maximum score achievable. Typically, you receive a maximum of 20-30 points per homework (more for the large homeworks), and 100 points per test, resulting in a maximum score of around 300 points.

We use a fixed grading system. There will be no adjustment based on the overall class performance. To earn a passing grade, you will have to achieve an overall score of at least 45%. The following table shows the percentage of your score you need to reach for a specific grade:

GradeMinimum percentage GradeMinimum percentage GradeMinimum percentage
A95% A-90%   
B+85% B80% B-75%
C+70% C65% C-60%
D+50% D45%   

OFFICE HOURS

Office hours: Need to be determined at class time.
Additional office hours by individual appointment in my office in Riverbend North, 155F.

HOMEWORKS

Homework Assignments

No. Homework Date assigned Date due Maximum Score
1 Imaging Fundamentals        
2 X-ray physics, Radiation, and Diagnostics        

LINKS

Here is a collection of some links I found interesting:

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